Comparison Between Blood-Brain Barrier Water Exchange Rate and Permeability to Gadolinium-Based Contrast Agent in an Elderly Cohort

Comparison Between Blood-Brain Barrier Water Exchange Rate and Permeability to Gadolinium-Based Contrast Agent in an Elderly Cohort

Background: Dynamic contrast-enhanced (DCE) MRI using intravenous injection of gadolinium-based contrast agents (GBCAs) is commonly used for imaging blood-brain barrier (BBB) permeability. Water is an alternative endogenous tracer with limited exchange rate across the BBB. A direct comparison betwee...

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Bibliographic Details
Main Authors: Xingfeng Shao, Kay Jann, Samantha J. Ma, Lirong Yan, Axel Montagne, John M. Ringman, Berislav V. Zlokovic, Danny J. J. Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Neuroscience
Subjects:
blood-brain barrier (BBB)
water exchange rate
permeability
arterial spin labeling (ASL)
white matter hyperintensity (WMH)
cerebral small vessel disease (CSVD)
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2020.571480/full

Internet

https://www.frontiersin.org/articles/10.3389/fnins.2020.571480/full

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