Modeling of the Bioactivation of an Organic Nitrate by a Thiol to Form a Thionitrate Intermediate

Modeling of the Bioactivation of an Organic Nitrate by a Thiol to Form a Thionitrate Intermediate

Thionitrates (R–SNO2) have been proposed as key intermediates in the biotransformation of organic nitrates that have been used for the clinical treatment of angina pectoris for over 100 years. It has been proposed and widely accepted that a thiol would react with an organic nitrate to afford a thion...

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Bibliographic Details
Main Authors: Tsukasa Sano, Keiichi Shimada, Yohei Aoki, Takayuki Kawashima, Shohei Sase, Kei Goto
Format: Article
Language:English
Published: MDPI AG 2016-12-01
Series:Molecules
Subjects:
thionitrates
reactive intermediates
kinetic stabilization
organic nitrates
nitric oxide
biotransformation
X-ray crystallographic analysis
Online Access:http://www.mdpi.com/1420-3049/22/1/19

Internet

http://www.mdpi.com/1420-3049/22/1/19

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