Oridonin Prolongs the Survival of Mouse Cardiac Allografts by Attenuating the NF-κB/NLRP3 Pathway

Oridonin Prolongs the Survival of Mouse Cardiac Allografts by Attenuating the NF-κB/NLRP3 Pathway

BackgroundOridonin (Ori), the main bioactive ingredient of the natural anti-inflammatory herb Rabdosia rubescens, could be a covalent inhibitor of the NLRP3 inflammasome. Solid organ transplantation provides a life-saving optional therapy for patients with end-stage organ dysfunction. The long-term...

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Bibliographic Details
Main Authors: Xiaoxiao Du, Weitao Que, Xin Hu, Xiao Yu, Wen-Zhi Guo, Shuijun Zhang, Xiao-Kang Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Immunology
Subjects:
oridonin
cardiac transplantation
NLRP3 inflammasome
acute rejection (AR)
adaptive immune
BMDC
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.719574/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.719574/full

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