Signaling diversity enabled by Rap1-regulated plasma membrane ERK with distinct temporal dynamics

Signaling diversity enabled by Rap1-regulated plasma membrane ERK with distinct temporal dynamics

A variety of different signals induce specific responses through a common, extracellular-signal regulated kinase (ERK)-dependent cascade. It has been suggested that signaling specificity can be achieved through precise temporal regulation of ERK activity. Given the wide distrubtion of ERK susbtrates...

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Bibliographic Details
Main Authors: Jeremiah Keyes, Ambhighainath Ganesan, Olivia Molinar-Inglis, Archer Hamidzadeh, Jinfan Zhang, Megan Ling, JoAnn Trejo, Andre Levchenko, Jin Zhang
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-05-01
Series:eLife
Subjects:
ERK
PC12
spatiotemporal
EGF
Rap1
signal transduction
Online Access:https://elifesciences.org/articles/57410

Internet

https://elifesciences.org/articles/57410

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