Adropin regulates pyruvate dehydrogenase in cardiac cells via a novel GPCR-MAPK-PDK4 signaling pathway

Adropin regulates pyruvate dehydrogenase in cardiac cells via a novel GPCR-MAPK-PDK4 signaling pathway

Mitochondria supply ~90% of the ATP required for contractile function in cardiac cells. While adult cardiomyocytes preferentially utilize fatty acids as a fuel source for oxidative phosphorylation, cardiac mitochondria can switch to other substrates when required. This change is driven in part by a...

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Bibliographic Details
Main Authors: Dharendra Thapa, Michael W. Stoner, Manling Zhang, Bingxian Xie, Janet R. Manning, Danielle Guimaraes, Sruti Shiva, Michael J. Jurczak, Iain Scott
Format: Article
Language:English
Published: Elsevier 2018-09-01
Series:Redox Biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231718304129

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http://www.sciencedirect.com/science/article/pii/S2213231718304129

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