S1P1 receptor modulation preserves vascular function in mesenteric and coronary arteries after CPB in the rat independent of depletion of lymphocytes.

S1P1 receptor modulation preserves vascular function in mesenteric and coronary arteries after CPB in the rat independent of depletion of lymphocytes.

BACKGROUND: Cardiopulmonary bypass (CPB) may induce systemic inflammation and vascular dysfunction. Sphingosine 1-phosphate (S1P) modulates various vascular and immune responses. Here we explored whether agonists of the S1P receptors, FTY720 and SEW2871 improve vascular reactivity after CPB in the r...

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Bibliographic Details
Main Authors: Iryna V Samarska, Hjalmar R Bouma, Hendrik Buikema, Hubert E Mungroop, Martin C Houwertjes, Anthony R Absalom, Anne H Epema, Robert H Henning
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4018292?pdf=render

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http://europepmc.org/articles/PMC4018292?pdf=render

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