Two distinct mechanisms target the autophagy-related E3 complex to the pre-autophagosomal structure

Two distinct mechanisms target the autophagy-related E3 complex to the pre-autophagosomal structure

In autophagy, Atg proteins organize the pre-autophagosomal structure (PAS) to initiate autophagosome formation. Previous studies in yeast revealed that the autophagy-related E3 complex Atg12-Atg5-Atg16 is recruited to the PAS via Atg16 interaction with Atg21, which binds phosphatidylinositol 3-phosp...

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Bibliographic Details
Main Authors: Kumi Harada, Tetsuya Kotani, Hiromi Kirisako, Machiko Sakoh-Nakatogawa, Yu Oikawa, Yayoi Kimura, Hisashi Hirano, Hayashi Yamamoto, Yoshinori Ohsumi, Hitoshi Nakatogawa
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-02-01
Series:eLife
Subjects:
autophagy
autophagosome
Atg protein
ubiquitin-like protein
Online Access:https://elifesciences.org/articles/43088

Internet

https://elifesciences.org/articles/43088

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