Whole genome sequence analysis suggests intratumoral heterogeneity in dissemination of breast cancer to lymph nodes.

Whole genome sequence analysis suggests intratumoral heterogeneity in dissemination of breast cancer to lymph nodes.

BACKGROUND:Intratumoral heterogeneity may help drive resistance to targeted therapies in cancer. In breast cancer, the presence of nodal metastases is a key indicator of poorer overall survival. The aim of this study was to identify somatic genetic alterations in early dissemination of breast cancer...

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Bibliographic Details
Main Authors: Kevin Blighe, Laura Kenny, Naina Patel, David S Guttery, Karen Page, Julian H Gronau, Cyrus Golshani, Justin Stebbing, R Charles Coombes, Jacqueline A Shaw
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4278903?pdf=render

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http://europepmc.org/articles/PMC4278903?pdf=render

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