Human corneal limbal organoids maintaining limbal stem cell niche function

Corneal epithelial stem cells reside in the limbal area between the cornea and conjunctiva. We examined the potential use of limbal organoids as a source of transplantable limbal stem cells. After treating tissue with collagenase, limbal cells were seeded onto Matrigel and cultivated using limbal ph...

Full description

Bibliographic Details
Main Authors: Kazunari Higa, Junko Higuchi, Reona Kimoto, Hideyuki Miyashita, Jun Shimazaki, Kazuo Tsubota, Shigeto Shimmura
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:Stem Cell Research
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S1873506120303135