The diabetic microenvironment causes mitochondrial oxidative stress in glomerular endothelial cells and pathological crosstalk with podocytes

The diabetic microenvironment causes mitochondrial oxidative stress in glomerular endothelial cells and pathological crosstalk with podocytes

Abstract Background In the setting of diabetes mellitus, mitochondrial dysfunction and oxidative stress are important pathogenic mechanisms causing end organ damage, including diabetic kidney disease (DKD), but mechanistic understanding at a cellular level remains obscure. In mouse models of DKD, gl...

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Bibliographic Details
Main Authors: Gabriella A. Casalena, Liping Yu, Roberto Gil, Samuel Rodriguez, Shantel Sosa, William Janssen, Evren U. Azeloglu, Jeremy S. Leventhal, Ilse S. Daehn
Format: Article
Language:English
Published: BMC 2020-07-01
Series:Cell Communication and Signaling
Subjects:
Endothelial cells
Diabetes
Crosstalk
Podocytes
Mitochondria
ROS
Online Access:http://link.springer.com/article/10.1186/s12964-020-00605-x

Internet

http://link.springer.com/article/10.1186/s12964-020-00605-x

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