Design, Synthesis and Pharmacological Evaluation of Naphthofuran Derivatives as Potent SIRT1 Activators

Design, Synthesis and Pharmacological Evaluation of Naphthofuran Derivatives as Potent SIRT1 Activators

Diabetic nephropathy (DN) is one of the most important medical complications in diabetic patients, which is an essential cause of end-stage renal disease in diabetic patients and still lacks effective medicines. Silent information regulator 1 (SIRT1) is closely related to the occurrence and developm...

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Bibliographic Details
Main Authors: Jian Gao, Qing-Qing Chen, Ye Huang, Kai-Hang Li, Xiao-Ju Geng, Tao Wang, Qi-Si Lin, Ruo-Si Yao
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Pharmacology
Subjects:
diabetic nephropathy
SIRT1 activators
virtual screening
apoptosis
inflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.653233/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.653233/full

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