Pneumolysin and the bacterial capsule of Streptococcus pneumoniae cooperatively inhibit taxis and motility of microglia

Pneumolysin and the bacterial capsule of Streptococcus pneumoniae cooperatively inhibit taxis and motility of microglia

Abstract Background Streptococcus pneumoniae is the cause of a highly lethal form of meningitis in humans. Microglial cells in the brain represent the first line of defense against pathogens, and they participate in the inflammatory response. The cholesterol-dependent cytolysin pneumolysin and the b...

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Bibliographic Details
Main Authors: Sabrina Hupp, Denis Grandgirard, Timothy J. Mitchell, Stephen L. Leib, Lucy J. Hathaway, Asparouh I. Iliev
Format: Article
Language:English
Published: BMC 2019-05-01
Series:Journal of Neuroinflammation
Subjects:
Microglia
Bacterial capsule
Pneumolysin
Streptococcus pneumoniae
Meningitis
Online Access:http://link.springer.com/article/10.1186/s12974-019-1491-7

Internet

http://link.springer.com/article/10.1186/s12974-019-1491-7

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