Fluorofenidone Alleviates Renal Fibrosis by Inhibiting Necroptosis Through RIPK3/MLKL Pathway

Fluorofenidone Alleviates Renal Fibrosis by Inhibiting Necroptosis Through RIPK3/MLKL Pathway

Cell death and sterile inflammation are major mechanisms of renal fibrosis, which eventually develop into end-stage renal disease. “Necroptosis” is a type of caspase-independent regulated cell death, and sterile inflammatory response caused by tissue injury is strongly related to necrosis. Fluorofen...

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Bibliographic Details
Main Authors: Qin Dai, Yan Zhang, Xiaohua Liao, Yupeng Jiang, Xin Lv, Xiangning Yuan, Jie Meng, Yanyun Xie, Zhangzhe Peng, Qiongjing Yuan, LiJian Tao, Ling Huang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Pharmacology
Subjects:
fluorofenidone
necroptosis
receptor-interacting protein kinase 3-mixed lineage kinase domain-like protein pathway
inflammation
renal fibrosis
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2020.534775/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2020.534775/full

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