<em>Closo</em>-Carboranyl- and Metallacarboranyl [1,2,3]triazolyl-Decorated Lapatinib-Scaffold for Cancer Therapy Combining Tyrosine Kinase Inhibition and Boron Neutron Capture Therapy

<em>Closo</em>-Carboranyl- and Metallacarboranyl [1,2,3]triazolyl-Decorated Lapatinib-Scaffold for Cancer Therapy Combining Tyrosine Kinase Inhibition and Boron Neutron Capture Therapy

One of the driving forces of carcinogenesis in humans is the aberrant activation of receptors; consequently, one of the most promising mechanisms for cancer treatment is receptor inhibition by chemotherapy. Although a variety of cancers are initially susceptible to chemotherapy, they eventually deve...

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Bibliographic Details
Main Authors: Marcos Couto, Catalina Alamón, María Fernanda García, Mariángeles Kovacs, Emiliano Trias, Susana Nievas, Emiliano Pozzi, Paula Curotto, Silvia Thorp, María Alejandra Dagrosa, Francesc Teixidor, Clara Viñas, Hugo Cerecetto
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Cells
Subjects:
tyrosine kinase inhibitors
lapatinib
[1,2,3]triazolyl linker
boron clusters
in vitro BNCT effect
Online Access:https://www.mdpi.com/2073-4409/9/6/1408

Internet

https://www.mdpi.com/2073-4409/9/6/1408

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