Arsenic trioxide induces expression of BCL-2 expression via NF-κB and p38 MAPK signaling pathways in BEAS-2B cells during apoptosis

Arsenic trioxide induces expression of BCL-2 expression via NF-κB and p38 MAPK signaling pathways in BEAS-2B cells during apoptosis

Inorganic arsenic compounds are environmental toxicants that are widely distributed in air, water, and food. B-cell lymphoma 2 (BCL-2) is an oncogene having anti-apoptotic function. In this study, we clarify that BCL-2, as a pro-apoptotic factor, participates in As2O3-induced apoptosis in BEAS-2B ce...

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Bibliographic Details
Main Authors: Jing Tang, Chenjuan Yao, Yingqi Liu, Jiaming Yuan, Li Wu, Kazuo Hosoi, Shali Yu, Chunyan Huang, Haiyan Wei, Gang Chen
Format: Article
Language:English
Published: Elsevier 2021-10-01
Series:Ecotoxicology and Environmental Safety
Subjects:
Arsenic trioxide
BCL-2
Apoptosis
p38 MAPK
Phosphorylation
NF-κB
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651321006436

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http://www.sciencedirect.com/science/article/pii/S0147651321006436

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