Substitution of the Native Zn(II) with Cd(II), Co(II) and Ni(II) Changes the Downhill Unfolding Mechanism of Ros87 to a Completely Different Scenario

Substitution of the Native Zn(II) with Cd(II), Co(II) and Ni(II) Changes the Downhill Unfolding Mechanism of Ros87 to a Completely Different Scenario

The structural effects of zinc replacement by xenobiotic metal ions have been widely studied in several eukaryotic and prokaryotic zinc-finger-containing proteins. The prokaryotic zinc finger, that presents a bigger βββαα domain with a larger hydrophobic core with respect to its eukaryotic counterpa...

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Bibliographic Details
Main Authors: Rinaldo Grazioso, Sara García-Viñuales, Luigi Russo, Gianluca D’Abrosca, Sabrina Esposito, Laura Zaccaro, Rosa Iacovino, Danilo Milardi, Roberto Fattorusso, Gaetano Malgieri, Carla Isernia
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:International Journal of Molecular Sciences
Subjects:
cadmium
cobalt
folding mechanism
nickel
zinc finger
Online Access:https://www.mdpi.com/1422-0067/21/21/8285

Internet

https://www.mdpi.com/1422-0067/21/21/8285

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