New Factors Enhancing the Reactivity of Cysteines in Molten Globule-Like Structures

Protein cysteines often play crucial functional and structural roles, so they are emerging targets to design covalent thiol ligands that are able to modulate enzyme or protein functions. Some of these residues, especially those involved in enzyme mechanisms—including nucleophilic and reductive catal...

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Bibliographic Details
Main Authors: Giorgia Gambardella, Giada Cattani, Alessio Bocedi, Giorgio Ricci
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:International Journal of Molecular Sciences
Subjects:
Online Access:https://www.mdpi.com/1422-0067/21/18/6949