Cytokine response in cerebrospinal fluid of meningitis patients and outcome associated with pneumococcal serotype

Abstract Streptococcus pneumoniae causes life-threatening meningitis. Its capsular polysaccharide determines the serotype and influences disease severity but the mechanism is largely unknown. Due to evidence of elevated cytokines levels in the meningeal inflammatory response, we measured 41 cytokine...

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Bibliographic Details
Main Authors: Annelies Müller, Diana B. Schramm, Jackie Kleynhans, Linda de Gouveia, Susan Meiring, Alban Ramette, Anne von Gottberg, Lucy Jane Hathaway
Format: Article
Language:English
Published: Nature Publishing Group 2021-10-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-99190-3