The Energy Status of Astrocytes Is the Achilles’ Heel of eIF2B-Leukodystrophy

The Energy Status of Astrocytes Is the Achilles’ Heel of eIF2B-Leukodystrophy

Translation initiation factor 2B (eIF2B) is a master regulator of global protein synthesis in all cell types. The mild genetic Eif2b5(R132H) mutation causes a slight reduction in eIF2B enzymatic activity which leads to abnormal composition of mitochondrial electron transfer chain complexes and impai...

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Bibliographic Details
Main Authors: Melisa Herrero, Maron Daw, Andrea Atzmon, Orna Elroy-Stein
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Cells
Subjects:
astrocytes
eIF2B-leukodystrophy
translation regulation
impaired mitochondria function
energy stress
oxidative stress
Online Access:https://www.mdpi.com/2073-4409/10/8/1858

Internet

https://www.mdpi.com/2073-4409/10/8/1858

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