The Therapeutic Targets of Fingolimod (FTY720) Are Involved in Pathological Processes in the Frontal Cortex of Alzheimer's Disease Patients: A Network Pharmacology Study

The Therapeutic Targets of Fingolimod (FTY720) Are Involved in Pathological Processes in the Frontal Cortex of Alzheimer's Disease Patients: A Network Pharmacology Study

Background: The sphingosine-1-phosphate receptor (S1PR) modulator fingolimod (FTY720), which is commonly used as an immunomodulator in multiple sclerosis treatment, has recently been found to reduce pathological changes in the brain tissue of Alzheimer's disease (AD) animal models, but this has...

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Bibliographic Details
Main Authors: Pengqi Yin, Yang Xue, Tingting Wang, Di Zhong, Guozhong Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Aging Neuroscience
Subjects:
Alzheimer's disease
fingolimod
S1PR1
network pharmacology
GABA synapses
frontal cortex
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2021.609679/full

Internet

https://www.frontiersin.org/articles/10.3389/fnagi.2021.609679/full

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