Transporter-Mediated Mitochondrial GSH Depletion Leading to Mitochondrial Dysfunction and Rescue with αB Crystallin Peptide in RPE Cells

Transporter-Mediated Mitochondrial GSH Depletion Leading to Mitochondrial Dysfunction and Rescue with αB Crystallin Peptide in RPE Cells

<b>: </b>Mitochondrial glutathione (mGSH) is critical for cell survival. We recently reported the localization of OGC (SLC25A11) and DIC (SLC25A10) in hRPE. Herein, we investigated the suppression of OGC and DIC and the effect of αB crystallin chaperone peptide co-treatment on RPE cell d...

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Bibliographic Details
Main Authors: Parameswaran G Sreekumar, Mo Wang, Christine Spee, Srinivas R. Sadda, Ram Kannan
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Antioxidants
Subjects:
mitochondrial membrane anion transporters
GSH carriers
αB crystallin peptide
bioenergetics
polarized RPE
Online Access:https://www.mdpi.com/2076-3921/9/5/411

Internet

https://www.mdpi.com/2076-3921/9/5/411

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