Structure and dynamics of the active Gs-coupled human secretin receptor

The class B secretin GPCR (SecR) has broad physiological effects, with target potential for treatment of metabolic and cardiovascular disease. Here, authors present a cryo-EM structure and biochemical studies of secretin binding to the SecR:Gs complex which show that interactions between peptide and...

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Main Authors:	Maoqing Dong, Giuseppe Deganutti, Sarah J. Piper, Yi-Lynn Liang, Maryam Khoshouei, Matthew J. Belousoff, Kaleeckal G. Harikumar, Christopher A. Reynolds, Alisa Glukhova, Sebastian G. B. Furness, Arthur Christopoulos, Radostin Danev, Denise Wootten, Patrick M. Sexton, Laurence J. Miller
Format:	Article
Language:	English
Published:	Nature Publishing Group 2020-08-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-020-17791-4

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spelling	doaj-35d3a9f45d2f49f5b92ff1e2f30c175a2021-08-22T11:41:26ZengNature Publishing GroupNature Communications2041-17232020-08-0111111710.1038/s41467-020-17791-4Structure and dynamics of the active Gs-coupled human secretin receptorMaoqing Dong0Giuseppe Deganutti1Sarah J. Piper2Yi-Lynn Liang3Maryam Khoshouei4Matthew J. Belousoff5Kaleeckal G. Harikumar6Christopher A. Reynolds7Alisa Glukhova8Sebastian G. B. Furness9Arthur Christopoulos10Radostin Danev11Denise Wootten12Patrick M. Sexton13Laurence J. Miller14Department of Molecular Pharmacology and Experimental Therapeutics, Mayo ClinicSchool of Biological Sciences, University of EssexDrug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash UniversityDrug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash UniversityDepartment of Molecular Structural Biology, Max Planck Institute of BiochemistryDrug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash UniversityDepartment of Molecular Pharmacology and Experimental Therapeutics, Mayo ClinicSchool of Biological Sciences, University of EssexDrug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash UniversityDrug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash UniversityDrug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash UniversityGraduate School of Medicine, University of TokyoDrug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash UniversityDrug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash UniversityDepartment of Molecular Pharmacology and Experimental Therapeutics, Mayo ClinicThe class B secretin GPCR (SecR) has broad physiological effects, with target potential for treatment of metabolic and cardiovascular disease. Here, authors present a cryo-EM structure and biochemical studies of secretin binding to the SecR:Gs complex which show that interactions between peptide and receptor were dynamic.https://doi.org/10.1038/s41467-020-17791-4
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Maoqing Dong Giuseppe Deganutti Sarah J. Piper Yi-Lynn Liang Maryam Khoshouei Matthew J. Belousoff Kaleeckal G. Harikumar Christopher A. Reynolds Alisa Glukhova Sebastian G. B. Furness Arthur Christopoulos Radostin Danev Denise Wootten Patrick M. Sexton Laurence J. Miller
spellingShingle	Maoqing Dong Giuseppe Deganutti Sarah J. Piper Yi-Lynn Liang Maryam Khoshouei Matthew J. Belousoff Kaleeckal G. Harikumar Christopher A. Reynolds Alisa Glukhova Sebastian G. B. Furness Arthur Christopoulos Radostin Danev Denise Wootten Patrick M. Sexton Laurence J. Miller Structure and dynamics of the active Gs-coupled human secretin receptor Nature Communications
author_facet	Maoqing Dong Giuseppe Deganutti Sarah J. Piper Yi-Lynn Liang Maryam Khoshouei Matthew J. Belousoff Kaleeckal G. Harikumar Christopher A. Reynolds Alisa Glukhova Sebastian G. B. Furness Arthur Christopoulos Radostin Danev Denise Wootten Patrick M. Sexton Laurence J. Miller
author_sort	Maoqing Dong
title	Structure and dynamics of the active Gs-coupled human secretin receptor
title_short	Structure and dynamics of the active Gs-coupled human secretin receptor
title_full	Structure and dynamics of the active Gs-coupled human secretin receptor
title_fullStr	Structure and dynamics of the active Gs-coupled human secretin receptor
title_full_unstemmed	Structure and dynamics of the active Gs-coupled human secretin receptor
title_sort	structure and dynamics of the active gs-coupled human secretin receptor
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2020-08-01
description	The class B secretin GPCR (SecR) has broad physiological effects, with target potential for treatment of metabolic and cardiovascular disease. Here, authors present a cryo-EM structure and biochemical studies of secretin binding to the SecR:Gs complex which show that interactions between peptide and receptor were dynamic.
url	https://doi.org/10.1038/s41467-020-17791-4
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Structure and dynamics of the active Gs-coupled human secretin receptor

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