RF9 Rescues Cortisol-Induced Repression of Testosterone Levels in Adult Male Macaques

Cortisol inhibits hypothalamic-pituitary-gonadal (HPG) axis whereas RF9, a potent agonist of kisspeptin receptor (GPR54) activates HPG-axis during fasting-induced stress and under normal physiological conditions. However, the effect of RF9 on the cortisol-induced repressed HPG-axis is not studied ye...

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Bibliographic Details
Main Authors: Rahim Ullah, Rabia Naz, Aalia Batool, Madiha Wazir, Tanzil Ur Rahman, Ghulam Nabi, Fazal Wahab, Junfen Fu, Muhammad Shahab
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Physiology
Subjects:
RF9
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2021.630796/full