Replicating Adenovirus-SIV Immunization of Rhesus Macaques Induces Mucosal Dendritic Cell Activation and Function Leading to Rectal Immune Responses

Replicating Adenovirus-SIV Immunization of Rhesus Macaques Induces Mucosal Dendritic Cell Activation and Function Leading to Rectal Immune Responses

Inducing strong mucosal immune responses by vaccination is important for providing protection against simian immunodeficiency virus (SIV). A replicating adenovirus type 5 host range mutant vector (Ad5hr) expressing SIV proteins induced mucosal immune responses in rectal tissue associated with delaye...

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Bibliographic Details
Main Authors: Eun-Ju Ko, Sabrina Helmold Hait, Gospel Enyindah-Asonye, Mohammad Arif Rahman, Tanya Hoang, Marjorie Robert-Guroff
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Immunology
Subjects:
dendritic cells
adenovirus-recombinant vaccine
rhesus macaque
simian immunodeficiency virus
mucosal immunity
rectal mucosa
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00779/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.00779/full

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