Elevated N‐methyltransferase expression induced by hepatic stellate cells contributes to the metastasis of hepatocellular carcinoma via regulation of the CD44v3 isoform

Elevated N‐methyltransferase expression induced by hepatic stellate cells contributes to the metastasis of hepatocellular carcinoma via regulation of the CD44v3 isoform

The cross‐talk between hepatic stellate cells (HSCs) and hepatic carcinoma cells contributes to hepatocellular carcinoma (HCC) progression, but the underlying mechanism is largely unknown. We report here that activated HSCs induce upregulation of nicotinamide N‐methyltransferase (NNMT), which is kno...

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Bibliographic Details
Main Authors: Jie Li, Song You, Sheng Zhang, Qing Hu, Fuqiang Wang, Xiaoqin Chi, Wenxiu Zhao, Chengrong Xie, Changmao Zhang, Yaqi Yu, Jianmin Liu, Yue Zhao, Pingguo Liu, Yi Zhang, Xujin Wei, Qiu Li, Xiaomin Wang, Zhenyu Yin
Format: Article
Language:English
Published: Wiley 2019-09-01
Series:Molecular Oncology
Subjects:
CD44
hepatic stellate cells
hepatocellular carcinoma
metastasis
NNMT
Online Access:https://doi.org/10.1002/1878-0261.12544

Internet

https://doi.org/10.1002/1878-0261.12544

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