RIP3 Inhibits Inflammatory Hepatocarcinogenesis but Promotes Cholestasis by Controlling Caspase-8- and JNK-Dependent Compensatory Cell Proliferation

RIP3 Inhibits Inflammatory Hepatocarcinogenesis but Promotes Cholestasis by Controlling Caspase-8- and JNK-Dependent Compensatory Cell Proliferation

For years, the term “apoptosis” was used synonymously with programmed cell death. However, it was recently discovered that receptor interacting protein 3 (RIP3)-dependent “necroptosis” represents an alternative programmed cell death pathway activated in many inflamed tissues. Here, we show in a gen...

Full description

Bibliographic Details
Main Authors: Mihael Vucur, Florian Reisinger, Jérémie Gautheron, Joern Janssen, Christoph Roderburg, David Vargas Cardenas, Karina Kreggenwinkel, Christiane Koppe, Linda Hammerich, Razq Hakem, Kristian Unger, Achim Weber, Nikolaus Gassler, Mark Luedde, Norbert Frey, Ulf Peter Neumann, Frank Tacke, Christian Trautwein, Mathias Heikenwalder, Tom Luedde
Format: Article
Language:English
Published: Elsevier 2013-08-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124713003975

Internet

http://www.sciencedirect.com/science/article/pii/S2211124713003975

Similar Items