Structure of Type IIL Restriction-Modification Enzyme MmeI in Complex with DNA Has Implications for Engineering New Specificities.

The creation of restriction enzymes with programmable DNA-binding and -cleavage specificities has long been a goal of modern biology. The recently discovered Type IIL MmeI family of restriction-and-modification (RM) enzymes that possess a shared target recognition domain provides a framework for eng...

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Bibliographic Details
Main Authors: Scott J Callahan, Yvette A Luyten, Yogesh K Gupta, Geoffrey G Wilson, Richard J Roberts, Richard D Morgan, Aneel K Aggarwal
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-04-01
Series:PLoS Biology
Online Access:http://europepmc.org/articles/PMC4833311?pdf=render