Effects of general versus subarachnoid anaesthesia on circadian melatonin rhythm and postoperative delirium in elderly patients undergoing hip fracture surgery: A prospective cohort clinical trial

Effects of general versus subarachnoid anaesthesia on circadian melatonin rhythm and postoperative delirium in elderly patients undergoing hip fracture surgery: A prospective cohort clinical trial

Background: Circadian rhythm disturbance is common postoperatively in older patients with hip fractures, which may contribute to the development of postoperative delirium (POD). As a reliable biomarker of endogenous circadian rhythms, melatonin regulates the sleep-wake cycle and environmental adapta...

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Bibliographic Details
Main Authors: Yanan Song, Yajie Liu, Yi Yuan, Xixi Jia, Wenchao Zhang, Geng Wang, Yunyang Jia, Xiaoxiao Wang, Lei Liu, Weitian Li, Xinping Li, Nan Cai, Chang Liu, Yue Li, Yongzheng Han, Yang Zhou, Xinning Mi, Chengmei Shi, John Q. Wang, Alain Vuylsteke, Xiangyang Guo, Zhengqian Li
Format: Article
Language:English
Published: Elsevier 2021-08-01
Series:EBioMedicine
Subjects:
Circadian rhythm
melatonin
general anaesthesia
subarachnoid anaesthesia
postoperative delirium
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396421002838

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http://www.sciencedirect.com/science/article/pii/S2352396421002838

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