BAX Redistribution Induces Apoptosis Resistance and Selective Stress Sensitivity in Human HCC

BAX Redistribution Induces Apoptosis Resistance and Selective Stress Sensitivity in Human HCC

Cancer therapies induce differential cell responses, ranging from efficient cell death to complete stress resistance. The BCL-2 proteins BAX and BAK govern the cellular decision between survival and mitochondrial apoptosis. Therefore, the status of BAX/BAK regulation can predict the cellular apoptos...

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Bibliographic Details
Main Authors: Kathrin Funk, Carolin Czauderna, Ramona Klesse, Diana Becker, Jovana Hajduk, Aline Oelgeklaus, Frank Reichenbach, Franziska Fimm-Todt, Joachim Lauterwasser, Peter R. Galle, Jens U. Marquardt, Frank Edlich
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Cancers
Subjects:
BCL-2 family
BH3
mitochondrial apoptosis
DNA damage
BH3 profiling
Online Access:https://www.mdpi.com/2072-6694/12/6/1437

Internet

https://www.mdpi.com/2072-6694/12/6/1437

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