Rationale and design of the Caloric Restriction and Exercise protection from Anthracycline Toxic Effects (CREATE) study: a 3-arm parallel group phase II randomized controlled trial in early breast cancer

Rationale and design of the Caloric Restriction and Exercise protection from Anthracycline Toxic Effects (CREATE) study: a 3-arm parallel group phase II randomized controlled trial in early breast cancer

Abstract Background Anthracycline chemotherapy agents are commonly used to treat breast cancer, but also result in cardiac injury, and potentially detrimental effects to vascular and skeletal muscle. Preclinical evidence demonstrates that exercise and caloric restriction can independently reduce ant...

Full description

Bibliographic Details
Main Authors: Amy A. Kirkham, D. Ian Paterson, Carla M. Prado, John M. Mackey, Kerry S. Courneya, Edith Pituskin, Richard B. Thompson
Format: Article
Language:English
Published: BMC 2018-09-01
Series:BMC Cancer
Subjects:
Anthracyclines
Cardiotoxicity
Breast cancer
Exercise
Caloric restriction
Magnetic resonance imaging
Online Access:http://link.springer.com/article/10.1186/s12885-018-4778-7

Internet

http://link.springer.com/article/10.1186/s12885-018-4778-7

Similar Items