IGF2/H19 hypomethylation in a patient with very low birthweight, preocious pubarche and insulin resistance

<p>Abstract</p> <p>Background</p> <p>Insulin like growth factor 2 (<it>IGF2</it>) is an imprinted gene, which has an important role in fetal growth as established in mice models. IGF2 is downregulated through hypomethylation of a differentially methylated re...

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Bibliographic Details
Main Authors: Murphy Rinki, Ibáñez Lourdes, Hattersley Andrew, Tost Jörg
Format: Article
Language:English
Published: BMC 2012-05-01
Series:BMC Medical Genetics
Subjects:
Online Access:http://www.biomedcentral.com/1471-2350/13/42