Loss of cIAP1 in Endothelial Cells Limits Metastatic Extravasation through Tumor-Derived Lymphotoxin Alpha

Loss of cIAP1 in Endothelial Cells Limits Metastatic Extravasation through Tumor-Derived Lymphotoxin Alpha

In this study, we determined whether Smac mimetics play a role in metastasis, specifically in circulation, tumor extravasation and growth in a metastatic site. Reports suggest inducing the degradation of IAPs through use of Smac mimetics, alters the ability of the tumor cell to metastasize. However,...

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Bibliographic Details
Main Authors: Lazaros Vasilikos, Kay Hänggi, Lisanne M. Spilgies, Samanta Kisele, Stefanie Rufli, W. Wei-Lynn Wong
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Cancers
Subjects:
cIAPs
Smac mimetics
tumor extravasation
endothelial barrier
permeability
lymphotoxin A
Online Access:https://www.mdpi.com/2072-6694/13/4/599

Internet

https://www.mdpi.com/2072-6694/13/4/599

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