IL-12p35 Inhibits Neuroinflammation and Ameliorates Autoimmune Encephalomyelitis

IL-12p35 Inhibits Neuroinflammation and Ameliorates Autoimmune Encephalomyelitis

Multiple sclerosis (MS) is an inflammatory demyelinating disease in which cytokines produced by immune cells that infiltrate the brain and spinal cord play a central role. We show here that the IL-12p35, the alpha subunit of IL-12 or IL-35 cytokine, might be an effective biologic for suppressing neu...

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Bibliographic Details
Main Authors: Jin Kyeong Choi, Ivy M. Dambuza, Chang He, Cheng-Rong Yu, Anita N. Uche, Mary J. Mattapallil, Rachel R. Caspi, Charles E. Egwuagu
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-10-01
Series:Frontiers in Immunology
Subjects:
biologic
multiple sclerosis
experimental autoimmune encephalomyelitis
IL-12p35
Breg cells
Treg cells
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01258/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.01258/full

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