Guanylate-binding protein 1 (Gbp1) contributes to cell-autonomous immunity against Toxoplasma gondii.

Guanylate-binding protein 1 (Gbp1) contributes to cell-autonomous immunity against Toxoplasma gondii.

IFN-γ activates cells to restrict intracellular pathogens by upregulating cellular effectors including the p65 family of guanylate-binding proteins (GBPs). Here we test the role of Gbp1 in the IFN-γ-dependent control of T. gondii in the mouse model. Virulent strains of T. gondii avoided recruitment...

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Bibliographic Details
Main Authors: Elizabeth M Selleck, Sarah J Fentress, Wandy L Beatty, Daniel Degrandi, Klaus Pfeffer, Herbert W Virgin, John D Macmicking, L David Sibley
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC3635975?pdf=render

Internet

http://europepmc.org/articles/PMC3635975?pdf=render

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