MAGI1 inhibits the AMOTL2/p38 stress pathway and prevents luminal breast tumorigenesis

MAGI1 inhibits the AMOTL2/p38 stress pathway and prevents luminal breast tumorigenesis

Abstract Alterations to cell polarization or to intercellular junctions are often associated with epithelial cancer progression, including breast cancers (BCa). We show here that the loss of the junctional scaffold protein MAGI1 is associated with bad prognosis in luminal BCa, and promotes tumorigen...

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Bibliographic Details
Main Authors: Diala Kantar, Emilie Bousquet Mur, Maicol Mancini, Vera Slaninova, Yezza Ben Salah, Luca Costa, Elodie Forest, Patrice Lassus, Charles Géminard, Florence Boissière-Michot, Béatrice Orsetti, Charles Theillet, Jacques Colinge, Christine Benistant, Antonio Maraver, Lisa Heron-Milhavet, Alexandre Djiane
Format: Article
Language:English
Published: Nature Publishing Group 2021-03-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-85056-1

Internet

https://doi.org/10.1038/s41598-021-85056-1

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