Theoretical Investigations on Interactions of Arylsulphonyl Indazole Derivatives as Potential Ligands of VEGFR2 Kinase

Theoretical Investigations on Interactions of Arylsulphonyl Indazole Derivatives as Potential Ligands of VEGFR2 Kinase

Vascular endothelial growth factor receptor 2 (VEGFR2) is a key receptor in the angiogenesis process. The VEGFR2 expression is upregulated in many cancers so this receptor is an important target for anticancer agents. In the present paper, we analyse interactions of several dimeric indazoles, previo...

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Bibliographic Details
Main Authors: Kornelia Czaja, Jacek Kujawski, Paweł Śliwa, Rafał Kurczab, Radosław Kujawski, Anna Stodolna, Agnieszka Myślińska, Marek K. Bernard
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:International Journal of Molecular Sciences
Subjects:
azoles
kinases
VEGFR2 kinase
DFT calculations
semi-empirical calculations
docking
Online Access:https://www.mdpi.com/1422-0067/21/13/4793

Internet

https://www.mdpi.com/1422-0067/21/13/4793

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