MiR-146a Ameliorates Hemoglobin-Induced Microglial Inflammatory Response via TLR4/IRAK1/TRAF6 Associated Pathways

MiR-146a Ameliorates Hemoglobin-Induced Microglial Inflammatory Response via TLR4/IRAK1/TRAF6 Associated Pathways

Microglial activation and sustained inflammation in the brain can lead to neuronal damage. Hence, limiting microglial activation and brain inflammation is a good therapeutic strategy for inflammatory-associated central nervous disease. MiR-146a is a promising therapeutic microRNA, since it can negat...

Full description

Bibliographic Details
Main Authors: Guang-Jie Liu, Qing-Rong Zhang, Xuan Gao, Han Wang, Tao Tao, Yong-Yue Gao, Yan Zhou, Xiang-Xin Chen, Wei Li, Chun-Hua Hang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Neuroscience
Subjects:
subarachnoid hemorrhage
microglial polarization
miR-146a
neuro-inflammation
TRAF6
IRAK1
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2020.00311/full

Internet

https://www.frontiersin.org/article/10.3389/fnins.2020.00311/full

Similar Items