Eye Drops of Metformin Prevents Fibrosis After Glaucoma Filtration Surgery in Rats via Activating AMPK/Nrf2 Signaling Pathway

Eye Drops of Metformin Prevents Fibrosis After Glaucoma Filtration Surgery in Rats via Activating AMPK/Nrf2 Signaling Pathway

Metformin has effective therapeutic effects in anti-tumor and anti-fibrotic diseases. However, how the antifibrotic effect of metformin in the eye and how it is transferred are still unclear. Here, the eye drop of metformin treatment was studied in Sprague–Dawley (SD) rats of glaucoma filtrating sur...

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Bibliographic Details
Main Authors: Xueru Li, Yu Leng, Qingzhi Jiang, Ziwen Wang, Peng Luo, Chi Zhang, Long Chen, Yawei Wang, Huilan Wang, Xiaofeng Yue, Chongxing Shen, Yuanlinhan Zhou, Chunmeng Shi, Lin Xie
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Pharmacology
Subjects:
glaucoma filtration surgery (GFS)
metformin
fibrosis
AMPK/Nrf2
oxidative stress
macrophages
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.01038/full

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https://www.frontiersin.org/article/10.3389/fphar.2020.01038/full

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