Notch ankyrin repeat domain variation influences leukemogenesis and Myc transactivation.

Notch ankyrin repeat domain variation influences leukemogenesis and Myc transactivation.

The functional interchangeability of mammalian Notch receptors (Notch1-4) in normal and pathophysiologic contexts such as cancer is unsettled. We used complementary in vivo, cell-based and structural analyses to compare the abilities of activated Notch1-4 to support T cell development, induce T cell...

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Bibliographic Details
Main Authors: Jon C Aster, Nick Bodnar, Lanwei Xu, Fredrick Karnell, John M Milholland, Ivan Maillard, Gavin Histen, Yunsun Nam, Stephen C Blacklow, Warren S Pear
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3192765?pdf=render

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http://europepmc.org/articles/PMC3192765?pdf=render

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