A Single High-Intensity Shock Wave Pulse With Microbubbles Opens the Blood-Brain Barrier in Rats

A Single High-Intensity Shock Wave Pulse With Microbubbles Opens the Blood-Brain Barrier in Rats

Focused extracorporeal shockwave (FSW), one kind of focused high-intensity pulsed ultrasound, has been shown to induce blood-brain barrier (BBB) opening in targeted brain areas in rat animal models with minimal detrimental effects below threshold intensity levels or iterations. In the current study,...

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Bibliographic Details
Main Authors: Yi Kung, Hsin-Yu Huang, Wei-Hao Liao, Abel P.-H. Huang, Ming-Yen Hsiao, Chueh-Hung Wu, Hao-Li Liu, Claude Inserra, Wen-Shiang Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
high-intensity pulsed ultrasound
blood-brain barrier
microbubbles
cavitation
safe dose
Online Access:https://www.frontiersin.org/article/10.3389/fbioe.2020.00402/full

Internet

https://www.frontiersin.org/article/10.3389/fbioe.2020.00402/full

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