Mycolactone cytotoxicity in Schwann cells could explain nerve damage in Buruli ulcer.

Buruli ulcer is a chronic painless skin disease caused by Mycobacterium ulcerans. The local nerve damage induced by M. ulcerans invasion is similar to the nerve damage evoked by the injection of mycolactone in a Buruli ulcer mouse model. In order to elucidate the mechanism of this nerve damage, we t...

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Bibliographic Details
Main Authors: Junichiro En, Sho Kitamoto, Akira Kawashima, Suguru Yonezawa, Yoshito Kishi, Norihisa Ishii, Masamichi Goto
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-08-01
Series:PLoS Neglected Tropical Diseases
Online Access:http://europepmc.org/articles/PMC5559071?pdf=render