Mycolactone cytotoxicity in Schwann cells could explain nerve damage in Buruli ulcer.

Mycolactone cytotoxicity in Schwann cells could explain nerve damage in Buruli ulcer.

Buruli ulcer is a chronic painless skin disease caused by Mycobacterium ulcerans. The local nerve damage induced by M. ulcerans invasion is similar to the nerve damage evoked by the injection of mycolactone in a Buruli ulcer mouse model. In order to elucidate the mechanism of this nerve damage, we t...

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Main Authors: Junichiro En, Sho Kitamoto, Akira Kawashima, Suguru Yonezawa, Yoshito Kishi, Norihisa Ishii, Masamichi Goto
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-08-01
Series:PLoS Neglected Tropical Diseases
Online Access:http://europepmc.org/articles/PMC5559071?pdf=render
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spelling doaj-361bc656c9f5454c94ff3f757c0d60ee2020-11-24T20:45:00ZengPublic Library of Science (PLoS)PLoS Neglected Tropical Diseases1935-27271935-27352017-08-01118e000583410.1371/journal.pntd.0005834Mycolactone cytotoxicity in Schwann cells could explain nerve damage in Buruli ulcer.Junichiro EnSho KitamotoAkira KawashimaSuguru YonezawaYoshito KishiNorihisa IshiiMasamichi GotoBuruli ulcer is a chronic painless skin disease caused by Mycobacterium ulcerans. The local nerve damage induced by M. ulcerans invasion is similar to the nerve damage evoked by the injection of mycolactone in a Buruli ulcer mouse model. In order to elucidate the mechanism of this nerve damage, we tested and compared the cytotoxic effect of synthetic mycolactone A/B on cultured Schwann cells, fibroblasts and macrophages. Mycolactone induced much higher cell death and apoptosis in Schwann cell line SW10 than in fibroblast line L929. These results suggest that mycolactone is a key substance in the production of nerve damage of Buruli ulcer.http://europepmc.org/articles/PMC5559071?pdf=render
collection DOAJ
language English
format Article
sources DOAJ
author Junichiro En
Sho Kitamoto
Akira Kawashima
Suguru Yonezawa
Yoshito Kishi
Norihisa Ishii
Masamichi Goto
spellingShingle Junichiro En
Sho Kitamoto
Akira Kawashima
Suguru Yonezawa
Yoshito Kishi
Norihisa Ishii
Masamichi Goto
Mycolactone cytotoxicity in Schwann cells could explain nerve damage in Buruli ulcer.
PLoS Neglected Tropical Diseases
author_facet Junichiro En
Sho Kitamoto
Akira Kawashima
Suguru Yonezawa
Yoshito Kishi
Norihisa Ishii
Masamichi Goto
author_sort Junichiro En
title Mycolactone cytotoxicity in Schwann cells could explain nerve damage in Buruli ulcer.
title_short Mycolactone cytotoxicity in Schwann cells could explain nerve damage in Buruli ulcer.
title_full Mycolactone cytotoxicity in Schwann cells could explain nerve damage in Buruli ulcer.
title_fullStr Mycolactone cytotoxicity in Schwann cells could explain nerve damage in Buruli ulcer.
title_full_unstemmed Mycolactone cytotoxicity in Schwann cells could explain nerve damage in Buruli ulcer.
title_sort mycolactone cytotoxicity in schwann cells could explain nerve damage in buruli ulcer.
publisher Public Library of Science (PLoS)
series PLoS Neglected Tropical Diseases
issn 1935-2727
1935-2735
publishDate 2017-08-01
description Buruli ulcer is a chronic painless skin disease caused by Mycobacterium ulcerans. The local nerve damage induced by M. ulcerans invasion is similar to the nerve damage evoked by the injection of mycolactone in a Buruli ulcer mouse model. In order to elucidate the mechanism of this nerve damage, we tested and compared the cytotoxic effect of synthetic mycolactone A/B on cultured Schwann cells, fibroblasts and macrophages. Mycolactone induced much higher cell death and apoptosis in Schwann cell line SW10 than in fibroblast line L929. These results suggest that mycolactone is a key substance in the production of nerve damage of Buruli ulcer.
url http://europepmc.org/articles/PMC5559071?pdf=render
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