Increased Plasma Level of 24S-Hydroxycholesterol and Polymorphism of CYP46A1 SNP (rs754203) Are Associated With Mild Cognitive Impairment in Patients With Type 2 Diabetes

Increased Plasma Level of 24S-Hydroxycholesterol and Polymorphism of CYP46A1 SNP (rs754203) Are Associated With Mild Cognitive Impairment in Patients With Type 2 Diabetes

BackgroundAbnormal cholesterol metabolism is common in type 2 diabetes mellitus (T2DM) and causes dementia. Cholesterol 24S-hydroxylase (CYP46A1) converts cholesterol into 24S-hydroxycholesterol (24-OHC) and maintains cholesterol homeostasis in the brain.ObjectiveThis study aimed to investigate the...

Full description

Bibliographic Details
Main Authors: Jijing Shi, Jianhong Jia, Sai Tian, Haoqiang Zhang, Ke An, Wenwen Zhu, Wuyou Cao, Yang Yuan, Shaohua Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Aging Neuroscience
Subjects:
type 2 diabetes mellitus
executive function
attention function
mild cognitive impairment
24S-hydroxycholesterol
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2021.619916/full

Internet

https://www.frontiersin.org/articles/10.3389/fnagi.2021.619916/full

Similar Items