Chd1 protects genome integrity at promoters to sustain hypertranscription in embryonic stem cells

Chd1 protects genome integrity at promoters to sustain hypertranscription in embryonic stem cells

The chromatin remodeler Chd1 mediates hypertranscription in embryonic stem (ES) cells and has been shown to associate with genes transcribed by RNA Polymerase (Pol) I and II. Here the authors provide mechanistic insights into this process and reveal that Chd1 is involved in protecting genome integri...

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Bibliographic Details
Main Authors: Aydan Bulut-Karslioglu, Hu Jin, Yun-Kyo Kim, Brandon Cho, Marcela Guzman-Ayala, Andrew J. K. Williamson, Miroslav Hejna, Maximilian Stötzel, Anthony D. Whetton, Jun S. Song, Miguel Ramalho-Santos
Format: Article
Language:English
Published: Nature Publishing Group 2021-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-25088-3

Internet

https://doi.org/10.1038/s41467-021-25088-3

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