Structure–Effect Relationships of Novel Semi-Synthetic Cannabinoid Derivatives

Structure–Effect Relationships of Novel Semi-Synthetic Cannabinoid Derivatives

Background: As a library of cannabinoid (CB) derivatives with (-)-trans-cannabidiol (CBD) or (-)-trans-cannabidivarin (CBDV) scaffold, we synthesized nine novel cannabinoids: 2-hydroxyethyl cannabidiolate (2-HEC), 2-hydroxypentyl cannabidiolate (2-HPC), 2,3-dihydroxypropyl cannabidiolate (GCBD), cyc...

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Bibliographic Details
Main Authors: Marcus R. Götz, Juan A. Collado, Javier Fernández-Ruiz, Bernd L. Fiebich, Laura García-Toscano, María Gómez-Cañas, Oskar Koch, Andreas Leha, Eduardo Muñoz, Carmen Navarrete, Maria R. Pazos, Ulrike Holzgrabe
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Pharmacology
Subjects:
cannabidiol
cannabidivarin
CBD
CBDV
CB-receptor
agonist
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.01284/full

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