Synthesis and Evaluation of Novel Pyrazole Ethandiamide Compounds as Inhibitors of Human THP-1 Monocytic Cell Neurotoxicity

Synthesis and Evaluation of Novel Pyrazole Ethandiamide Compounds as Inhibitors of Human THP-1 Monocytic Cell Neurotoxicity

Neuroinflammation and microglia-mediated neurotoxicity contribute to the pathogenesis of a broad range of neurodegenerative diseases; therefore, identifying novel compounds that can suppress adverse activation of glia is an important goal. We have previously identified a class of trisubstituted pyra...

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Bibliographic Details
Main Authors: Jordan A. McKenzie, Reham F. Barghash, Azhaar T. Alsaggaf, Omkar Kulkarni, Kalun Boudreau, Frederic Menard, Edward G. Neeland, Andis Klegeris
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:Cells
Subjects:
anti-inflammatory drugs
chemical synthesis
cytotoxicity
microglia models
neuroinflammation
neuroprotection
SH-SY5Y neuroblastoma
THP-1 monocytic cells
Online Access:https://www.mdpi.com/2073-4409/8/7/655

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https://www.mdpi.com/2073-4409/8/7/655

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