Macrophages From Subjects With Isolated GH/IGF-I Deficiency Due to a GHRH Receptor Gene Mutation Are Less Prone to Infection by Leishmania amazonensis

Macrophages From Subjects With Isolated GH/IGF-I Deficiency Due to a GHRH Receptor Gene Mutation Are Less Prone to Infection by Leishmania amazonensis

Isolated growth hormone (GH) deficiency (IGHD) affects approximately 1 in 4,000 to 1 in 10,000 individuals worldwide. We have previously described a large cohort of subjects with IGHD due to a homozygous mutation in the GH releasing hormone (GHRH) receptor gene. These subjects exhibit throughout the...

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Bibliographic Details
Main Authors: Mônica R. Barrios, Viviane C. Campos, Nalu T. A. Peres, Laís L. de Oliveira, Rodrigo A. Cazzaniga, Márcio B. Santos, Murilo B. Aires, Ricardo L. L. Silva, Aline Barreto, Hiro Goto, Roque P. Almeida, Roberto Salvatori, Manuel H. Aguiar-Oliveira, Amélia M. R. Jesus
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
growth hormone deficiency
insulin growth factor-I deficiency
macrophages
leishmaniasis
phagocytosis
infection
Online Access:https://www.frontiersin.org/article/10.3389/fcimb.2019.00311/full

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https://www.frontiersin.org/article/10.3389/fcimb.2019.00311/full

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