In vivo evaluation of urokinase-loaded hollow nanogels for sonothrombolysis on suture embolization-induced acute ischemic stroke rat model

In vivo evaluation of urokinase-loaded hollow nanogels for sonothrombolysis on suture embolization-induced acute ischemic stroke rat model

The urokinase-type plasminogen activator (uPA) loaded hollow nanogels (nUK) were synthesized by a one-step reaction of glycol chitosan and aldehyde capped poly (ethylene oxide). The resultant formulation is sensitive to diagnostic ultrasound (US) of 2 MHz. Herein, we evaluated the in vivo sonothromb...

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Bibliographic Details
Main Authors: Yuming Teng, Haiqiang Jin, Ding Nan, Mengnan Li, Chenghe Fan, Yuanyuan Liu, Pu Lv, Wei Cui, Yongan Sun, Hongjun Hao, Xiaozhong Qu, Zhenzhong Yang, Yining Huang
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2018-03-01
Series:Bioactive Materials
Subjects:
Hollow nanogel
Ultrasound responsive
Urokinase delivery
Thrombolysis
In vivo evaluation
Online Access:http://www.sciencedirect.com/science/article/pii/S2452199X17300737

Internet

http://www.sciencedirect.com/science/article/pii/S2452199X17300737

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