Mural cell dysfunction leads to altered cerebrovascular tau uptake following repetitive head trauma

Mural cell dysfunction leads to altered cerebrovascular tau uptake following repetitive head trauma

A pathological characteristic of repetitive traumatic brain injury (TBI) is the deposition of hyperphosphorylated and aggregated tau species in the brain and increased levels of extracellular monomeric tau are believed to play a role in the pathogenesis of neurodegenerative tauopathies. The pathways...

Full description

Bibliographic Details
Main Authors: Joseph Ojo, Max Eisenbaum, Ben Shackleton, Cillian Lynch, Utsav Joshi, Nicole Saltiel, Andrew Pearson, Charis Ringland, Daniel Paris, Benoit Mouzon, Michael Mullan, Fiona Crawford, Corbin Bachmeier
Format: Article
Language:English
Published: Elsevier 2021-03-01
Series:Neurobiology of Disease
Subjects:
Mural cells
Tau
Pericytes
Smooth muscle cells
Traumatic brain injury
Alzheimer's disease
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996120305131

Internet

http://www.sciencedirect.com/science/article/pii/S0969996120305131

Similar Items