The role of HFE genotype in macrophage phenotype

Abstract Background Iron regulation is essential for cellular energy production. Loss of cellular iron homeostasis has critical implications for both normal function and disease progression. The H63D variant of the HFE gene is the most common gene variant in Caucasians. The resulting mutant protein...

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Bibliographic Details
Main Authors: Anne M. Nixon, Elizabeth Neely, Ian A. Simpson, James R. Connor
Format: Article
Language:English
Published: BMC 2018-02-01
Series:Journal of Neuroinflammation
Subjects:
HFE
Online Access:http://link.springer.com/article/10.1186/s12974-018-1057-0